Since the general condition of cancer patients is usually impaired, there is a high possibility of facing problems in surgical treatment. Therefore, the Gamma Knife which provides a single stage treatment in metastatic treatment is very advantageous. It allows the patient to receive chemotherapy or other therapies at the same time when treating lesions in the patient's brain effectively and does not cause a delay in the systemic treatment of cancer. When whole brain irradiation is used in patients with brain metastasis, memory disorders and dementia are very common, and the quality of life of the patient is severely reduced. In addition, Gamma Knife is successfully used in the treatment of multiple brain metastases. It is well-known that Gamma Knife is better technique which protected normal brain tissue than other radiotherapy techniques.
Pituitary adenomas arising from the pituitary gland that is responsible for hormone secretion in the brain. Pituitary adenomas can manifest themselves with hormonal imbalance or vision loss. Medications, surgical methods and Gamma Knife can be used in the treatment of these tumors. Gamma Knife radiosurgery provides effective and safe treatment especially for pituitary tumors with high recurrence and high surgical risk.
Meningiomas are usually benign tumors and they are taking origin from cap cells of brain membrane. Although surgical treatment is the first choice, the risk of surgery may be higher than in the area where meningiomas are present and it may not be possible to remove them completely. In this case, Gamma Knife radiosurgery offers an effective and safe treatment option. Gamma Knife may reduce the high risk of surgeries particularly in skull base meningiomas.
Vestibular Schwannoma (Acoustic Neuroma)
Vestibular schwannomas are benign tumors arising from the nerve responsible from hearing and balance. Hearing loss at various ratios, ear tinnitus and imbalance are the most common symptoms of these benign tumors. Although surgical intervention is the choice for the lesions larger than 3.5-4 cm, after reports that described high control and effectiveness treatment, Gamma Knife treatment has become the standard treatment for medium and small lesions. Compared to open surgery, the risk of hearing loss and facial paralysis is much less in the treatment with Gamma Knife. In addition, the risks of infection, hemorrhage, and CSF fistula caused by the surgical interventions are not present in the Gamma Knife treatment.
Arteriovenous malformations (AVMs) are abnormal vascular bundles seen in the brain. AVMs can cause hemorrhage, weakness and seizures. Brain hemorrhage that may develop leads to very serious clinical problems. Moreover, the seizures they cause are reducing the quality of life of the patient.
AVMs can be surgically removed, clogged with the method called embolization, or destroyed by radiosurgery. Sometimes these methods are used in addition to each other. However, surgical treatment of AVMs, especially in the deep-located or brain eloquent regions of the brain, is very risky and sometimes surgical intervention is not possible. In this patient group, the Gamma Knife provides a very effective and safe treatment option.
Trigeminal neuralgia is characterized by sudden and violent lightning strikes that last from a few seconds to a few minutes in the mid-half of the distribution of the trigeminal nerve. Due to severe pain in patients with trigeminal neuralgia, their quality of life deteriorates further and they are exposed to side effects because they increase the doses of the medications they use. Gamma Knife therapy is a highly effective treatment option for these patients and is more effective than local injection procedures and may reduce the addictions of the medications.
"Gamma Knife, which is an effective treatment modality for trigeminal neuralgia, and reduces the addiction of the medications and increases the quality of life."
Gamma Knife radiosurgery is an effective non-invasive technique that is used to treat metastatic tumors. Gamma knife is nonsurgical very sensitive technique that impact on the brain lesion via beam of radiation. Gamma Knife prevents the complications that may happen in open surgery such as bleeding, infection and complications related to general anesthesia. Use of this technique may protect patients from the complications that may occur as a result of long length hospital stay periods.
Gamma Knife radiosurgery is a particularly recommended treatment for patients with surgical co-morbidities due to their advanced age or medical conditions. Gamma Knife treatment is very advantageous for the cases in which general anesthesia is contraindicated.
Gamma Knife radiosurgery is usually a one-time therapy completed in a single day. Unlike an open surgery, the patients whom are received Gamma Knife do not need to be hospitalized and do not need intensive care. This gives patients and their relatives a high comfort.
The stereotactic Leksell® frame used to fix the patient's head in the Gamma Knife treatment is more sensitive than other radiotherapy techniques. Thus, normal brain tissue is more safe and protected.
Gamma Knife can be used in the following conditions:
· Benign and Malignant brain tumors
· Brain Metastasis
· Diseases that cause neuralgia on face
· Vascular disorders
"The patients who receive Gamma Knife treatment do not feel pain"
Gamma Knife radiosurgery uses 201 high energy
Co-60 resource tiny beam of radiation to focus on a lesion (tumor/vascular
malformation) or other target in the brain with a perfect accuracy. Although
each beam has very little effect on the brain tissue, that passes through, a
strong dose of radiation is delivered to the place where all the beams meet.
These concentrated beams cause impairment or changes in a tumor or a vascular
lesion and also lead to stop an abnormal brain tissue's circles such as those
happen in functional disorders (e.g. trigeminal neuralgia).
Üniversitemiz, dünyanın en prestijli kongreleri arasında gösterilen "16. Dünya Beyin Cerrahi Kongresi"nde yerini aldı. 21 – 25 Ağustos tarihleri arasında İstanbul Kongre Merkezi'nde düzenlenen kongrede Üniversitemizi Beyin ve Sinir Cerrahisi Anabilim Dalı Başkanımız Doç. Dr. Mustafa Aziz Hatiboğlu, Beyin ve Sinir Cerrahisi Anabilim Dalımızdan Uz. Dr. Anas Abdallah, Uz. Dr. Erdinç Özek ve Uz. Dr. Tolga Turan Dündar, Araştırmacı Arife Nallı, Tıp Fakültesi 6. sınıf öğrencimiz Halil Akdağ, Tıp Fakültesi 6. sınıf öğrencimiz Hande Şişman temsil ederek dünyanın dört bir yanından gelen katılımcıların sorularını yanıtladı. Yoğun ilgi gösterilen standımızda yakın coğrafyada bulunan ülkelerin bilim adamlarına yetkin akademik kadromuz ve tedavi yöntemlerimiz hakkında bilgiler verildi. Gamma Knife Ünitesi hakkında çeşitli görüş ve eğitim talepleri konusunda fikir alışverişlerinin bulunulduğu kongrede Dünya Beyin Cerrahi Kongresi Danışma Kurulu bünyesinde yer alan Doç. Dr. Mustafa Aziz Hatiboğlu'nun yönettiği "Beyin Tümörlerinin Kök Hücreyle Tedavisinde Yenilikler'' adlı oturum büyük yankı uyandırdı.
16. Dünya Beyin Cerrahi Kongresi'nde Akademisyen ve Öğrencilerimizin Gerçekleştirdiği Sunumlar;
Doç Dr. Mustafa Aziz Hatiboğlu
Tekerrür eden Yüksek Gradli Glial Tümörü olan hastalar üzerinde Gamma Knife Işınlı Ameliyat Etkisinin Değerlendirilmesi
Uz. Dr. Anas Abdallah
Bağlanmış Cord Sendromlu Yetişkin Hastalardaki Ameliyat Sonuçlarını Etkileyen Faktörler : Geçmişe Yönelik Bir Araştırma
Uz. Dr. Erdinç Özek
Çerçevesiz Nöronavigasyon Destekli Beyin Biyopsisi : Güvenlik, Verimlilik ve Tecrübemiz
Uz. Dr. Tolga Turan Dündar
TOF MRA Kıyaslaması, Kontrast – Artışlı MRA ve Tedavi Edilmiş Intrakraniyal Kanamalardaki Artık Değerlendirilmesinde CTP'den Çıkarılmış CTA
Tıp Fakültesi 6. Sınıf Öğrencisi Halil Akdağ
Trigeminal Nevralji Hastalarındaki Gamma Knife Işınlı Ameliyatın Etkisi
Tıp Fakültesi 6. Sınıf Öğrencisi Hande Şişman
Timokinon, Apopotosis U87 İnsan glioma Hücrelerini Başlatım ile Etkili Bir Tedavidir
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